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Work package A1
CD30 signalling in normal B-cell development and tumorigenesis


Work package A2
Functional implications of selectively NF-κB/Rel- and IKK-mediated Gene Signatures in Hodgkin Lymphoma Cells and in Lymphomagenesis


Work package A3
Evaluation of IKK2/β Inhibition as targeted Therapy  in B Cell Lymphomas and the Role of c-Rel Overexpression in B Cell Lymhomagenesis


Work package A4
Functional Plasticity of hypermutating B Cell Lymphomas


Work package A5
Functional Characterization of the SET Domain Protein BCL 12 that is deregulated in diffuse large B Cell Lymphoma by an Immunoglobulin Gene Translocation


Work package A6
The Role of Differentiation Status and Plasticity of the Lymphoma-initiating  Cell in Pathogenesis of large Cell anaplastic Lymphoma in a conditional NPM-ALK Model


Work package A7
Drug-induced apoptosis and senescence: interaction with the adaptive immune system in c-myc induced murine B cell lymphomas


Work package B1
The patho-physiological Role of Lineage-specific Transcription Factors, PU.1 and C/EBPα, in Identity and Tumorigenesis of B lymphatic Neoplasisas


Work package B2
Molecular Genetics of C/EBP mediated myeloid-lymphoid Plasticity


Work package B3
Epigenetic Components of cellular Transdifferentiation in molecular Pathogenesis of Hodgkin Lymphoma and diffuse large B Cell Lymphoma


Work package B4
The role of epigenetic changes and cellular transdifferentiation in the molecular pathogenesis of Hodgkin lymphoma and diffuse large B-cell lymphoma


Work package B5
The Importance of E2F6/Polycomb Complexes for Identity of normal lymphatic Cells and its Deregulation in lymphatic Neoplasias


Work package B6
Functional dissection and targeting of aberrant differentiation through deregulated Notch Signaling in Hodgkin Lymphoma and Multiple Myeloma


Work package C2
Non-cell-autonomous Impact of Treatment-induced Senescence of Lymphoma Growth in vivo


Work package C3
Dissection of Stroma-derived Deregulation of Cell-Cycle Progression and Apoptosis in a Subset of CLL Cells with Progenitor Attributes


Work package C4
Niche Function of immature osteoblastic Cells of lymphatic Tumor Cells


Work package C5
The Role of Cks1 for Cell Cycle Progression p27Kip1 functionality, Tumorigenesis and Tumor Dissemination


Work package C6
The Role of non-malignant B Cells and immature myeloid Cells in Development and Progression of sporadic B Cell Neoplasias and solid Tumors


Work package Z1
Administration, Coordination, Organization, and scientific Integration


Work package Z2
Translation of Model-based Findings to primary human lymphoid Neoplasia


Work package Z3
The goal of subproject Z3 is to develop and maintain a comprehensive data management and analysis platform for the Transregio.